脳神経医学セミナー「小胞体Ca²⁺チャネル/IP₃受容体 ―細胞代謝での新しいパラダイムの確立―」

Event Details

【Title】Endoplasmic Reticulum Ca²⁺ Channels / IP₃ Receptors — Establishing a New Paradigm in Cellular Metabolism
【Speaker】Professor Katsuhiko Mikoshiba, Institute for Immunochemistry, ShanghaiTech University

Professor Mikoshiba discovered that the IP₃ receptor is the macromolecular membrane protein missing in mutant mice exhibiting ataxia, and he was the first in the world to successfully clone its cDNA. He demonstrated that IP₃ receptors generate intracellular calcium oscillations and proposed a novel concept that the endoplasmic reticulum—once considered merely a small intracellular organelle—regulates development, differentiation, motor function, and neural plasticity.

Through genetic analysis of patients, he identified IP₃ receptor type 1 as the causative gene of human spinocerebellar degeneration, revealing its deep involvement in disease. He further demonstrated that IP₃ receptors play key roles in cellular metabolism, including the Warburg effect in cancer, Bcl‑2 family–mediated apoptosis, ER stress responses, and viral replication and infection.

In recent years, Professor Mikoshiba’s research group has succeeded in developing STAND (ultra‑stable cytoplasmic antibody), a “stable intracellular antibody” that functions in soluble form without aggregation inside cells. This technology has opened new possibilities for understanding biological phenomena and treating diseases through intracellular protein manipulation. The seminar will introduce specific examples of these advances.

Professor Mikoshiba is internationally renowned as the discoverer of the IP₃ receptor. This is a rare opportunity to hear directly from him, and we encourage you to attend.​​

【Courses Eligible for Credit】
 -  Division of Medicine (Doctoral Course) , Graduate School of Medical Sciences
Course: Up‑to‑date Seminar

● School of Medicine
Course: Advanced Medical Research

Contact

Professor Hiroshi Kawasaki, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University    E-mail: kawasaki-labo(a)umin.ac.jp    *Please replace (a) with @.